Q: There is no way to know anything in my opinion.
A: Well then you must be wrong about that... haha! Get it?
I have found that when people are challenged to rethink their opinions about the nature of reality, they often come up with this idea that "nothing can be known" and therefore they need not take the challenge into consideration. This happens to me all the time, but less now than it used to.
In fact, to say that nothing can be known, aside from being an oxymoronic statement, means that there is no point in trying to liberate ourselves, since the path to freedom cannot be known. However, if we look at those who have attained the deathless, we see that most (all?) of them have used the mind to know the path out of mind (and thus out of suffering).
Buddha said that all of the teachings must eventually be left, just as one who crosses onto shore leaves their raft on the beach, but if one leaves the raft of logic while still in the ocean, they are in for some trouble.
Here is a post regarding how to view the mind practically, in a middle-path kind of way.
And here's a useful snippet I snagged:
And as Kyle Dixon quoted,
"…The process of eradicating avidyā is conceived… not as a mere stopping of thought, but as the active realization of the opposite of what ignorance misconceives. Avidyā is not a mere absence of knowledge, but a specific misconception, and it must be removed by realization of its opposite. In this vein, Tsongkhapa says that one cannot get rid of the misconception of 'inherent existence' merely by stopping conceptuality any more than one can get rid of the idea that there is a demon in a darkened cave merely by trying not to think about it. Just as one must hold a lamp and see that there is no demon there, so the illumination of wisdom is needed to clear away the darkness of ignorance."
Napper, Elizabeth, 2003, p. 103